BANGUI: Pope Francis ventured into one of the world's most dangerous neighbourhoods on Monday to beg Christians and Muslims to end a spiral of hate, vendetta and bloodshed that has killed thousands over the past three years.

Under intense security, Francis passed through a no-man's zone to enter PK5, a district where most Muslims who have not fled the capital of the Central African Republic (CAR) have now sought refuge.

The neighbourhood has been cut off from the rest of the capital Bangui for the past two months by a ring of so-called anti-balaka militias, who block supplies from entering and Muslims from leaving.

A heavy deployment of United Nations (UN) peacekeepers with rifles and bullet-proof vests was present throughout PK5 and armoured vehicles mounted with machineguns were positioned along the route of Pope Francis' motorcade.

UN sharpshooters looked out from the tops of the minarets crowning the freshly repainted green and white mosque, where hundreds of PK5's Muslims listened as Francis made an impassioned appeal for an end to the violence.

"Christians and Muslims are brothers and sisters," he said after a speech by Imam Tidiani Moussa Naibi, one of the local religious leaders trying to foster dialogue.

"Those who claim to believe in God must also be men and women of peace," he said, noting that Christians, Muslims and followers of traditional religions had lived together in peace for many years.

He appealed for "an end to every act which, from whatever side, disfigures the face of God and whose ultimate aim is to defend particular interests by any and all means."

CAR descended into chaos in early 2013 when Seleka rebels seized power in the country, sparking reprisals from certain militias. Leaders from both sides say the hate has been manipulated for political gain.

Healing rifts between Christian and Muslim communities has been a theme throughout Francis' first visit to the continent, which has also taken him to Kenya and Uganda.

However, nowhere is his call for peace and reconciliation more pressing than in CAR, where thousands have died and hundreds of thousands have been displaced in clashes that have split the country along religious lines.

Unprecedented security

"Together, we must say no to hatred, to revenge and to violence, particularly that violence which is perpetrated in the name of a religion or of God himself. God is peace, 'salam'," the pope said.

Unprecedented security measures have been laid on for the pontiff's two-day visit to the former French colony, which took place amid a surge in violence.

Tit-for-tat killings in and around the tiny PK5 enclave have claimed at least 100 lives since late September, according to Human Rights Watch.

Imam Naibi has called PK5 "an open-air prison", but on Monday he struck a optimistic tone.

"The relationship between our Christian brothers and sisters and ourselves is so deep that no manoeuvre seeking to undermine it will succeed," he told the pope. "The Christians and Muslims of this country are obliged to live together and love each other."

Both the Christian majority and the minority Muslims have welcomed the pope's visit, hoping he can spur renewed dialogue and help restore peace. Thousands of PK5's Muslims lined the road into the enclave to get a glimpse of the pontiff.

CAR's UN peacekeeping mission brought in additional forces and has deployed over 3,000 soldiers in an attempt to secure the city during the pope's visit.

The government is also contributing around 500 police and gendarmes. French troops based in Bangui are also on alert.

Pope Francis ends his Africa tour with a Mass for tens of thousands of Catholics at the country's national stadium before returning to Rome.