Scientists have found a biological command centre for the aging process in a lump of brain the size of a nut.

The US team identified the mechanism in the hypothalamus, which sits deep inside the brain, and showed that they could tweak it to shorten or lengthen the lives of animals.

In a series of experiments, the researchers found they could extend the lives of mice by a fifth, without the animals suffering from muscle weakness, bone loss or memory problems common in old age.

The work raises the tantalising prospect of drugs that slow down natural aging to prolong life in humans, but more crucially to prevent age-related diseases, such as diabetes, heart disease and Alzheimer’s.

“We’re very excited about this. It supports the idea that aging is more than a passive deterioration of different tissues. It is under control, and can be manipulated,” said Dongsheng Cai at the Albert Einstein College of Medicine in New York.

Writing in the journal Nature, the scientists describe how their research led them to what appears to be the body’s control centre for ageing. They found that a chemical called NF-kB became more active in the hypothalamus of mice as they got older.

When the researchers blocked the substance mice lived up to 1,100 days, compared with 600 to 1,000 days for normal healthy mice. When they boosted NF-kB in mice, they all died within 900 days.

Further work showed that NF-kB lowered levels of a hormone called GnRH, which is better known for the central role it plays in fertility and the development of sperm and eggs.

When the scientists gave old mice daily jabs of GnRH they found that this, too, extended the animals’ lives, and even caused fresh neurons to grow in their brains.Cai said there may be several ways to slow down ageing, with drugs that dampen the activity of NF-kB in the brain, or raise levels of GnRH. “For now we are going to work on understanding the mechanism,” he said.

In an accompanying article in Nature, Bruce Yankner at Harvard Medical School, and Dana Gabuzda at the Dana-Farber Cancer Institute in Boston, wrote that, if confirmed, the results could have “important implications for our understanding and treatment of age-related diseases”.

By arrangement with the Guardian

Opinion

Editorial

Faizabad redux
Updated 02 Oct, 2023

Faizabad redux

TLP was allowed to flourish despite its virulent ideology, recurrently causing immense embarrassment for Pakistani authorities in later years.
Exporting beggars
02 Oct, 2023

Exporting beggars

A RECENT revelation by the Senate Standing Committee on Overseas Pakistanis during a briefing to the Senate has...
Brutalising society
02 Oct, 2023

Brutalising society

THE Senate Standing Committee on Interior passed a bill last week with a majority vote that favoured the public...
Massacre again
Updated 01 Oct, 2023

Massacre again

If this monster is not vanquished at this stage, it will create a security nightmare of significant proportions.
A refuge no longer
01 Oct, 2023

A refuge no longer

SEPTEMBER has seen an alarming rise in the rounding up and detention of Afghan refugees. Pakistani authorities cite...
Whither justice?
01 Oct, 2023

Whither justice?

THE challenge is to ensure bestial tragedies are remembered. Two cases of femicide, involving men from Pakistan’s...