Indian scientists flag coronavirus mutations that could ‘evade immune response’

Published May 2, 2021
People get their names registered after receiving a dose of Covishield, a Covid-19 vaccine manufactured by Serum Institute of India, at a vaccination centre in Ahmedabad, India, May 1. — Reuters
People get their names registered after receiving a dose of Covishield, a Covid-19 vaccine manufactured by Serum Institute of India, at a vaccination centre in Ahmedabad, India, May 1. — Reuters

A forum of scientific advisers set up by the Indian government has told authorities about minor mutations in some samples of the coronavirus that could “possibly evade immune response” and require more study, a leader of the forum has told Reuters.

However, the advisers said while they were flagging the mutations, there was no reason currently to believe they were expanding or could be dangerous.

Scientists are studying what led to the current surge in cases in India and particularly whether a variant first detected in the country, called B.1.617, is to blame. The World Health Organisation (WHO) has not declared the Indian variant a “variant of concern,” as it has done for variants first detected in Britain, Brazil and South Africa. But the WHO said on April 27 that its early modelling, based on genome sequencing, suggested that B.1.617 had a higher growth rate than other variants circulating in India.

The forum of advisers, known as the Indian SARS-CoV-2 Genetics Consortium, or INSACOG, has now found more mutations in the coronavirus that it thinks need to be tracked closely.

"We are seeing some mutation coming up in some samples that could possibly evade immune responses," said Shahid Jameel, chair of the scientific advisory group of INSACOG and a top Indian virologist. He did not say if the mutations have been seen in the Indian variant or any other strain.

"Unless you culture those viruses and test them in the lab, you can't say for sure. At this point, there is no reason to believe that they are expanding or if they can be dangerous, but we flagged it so that we keep our eye on the ball," he said.

INSACOG brings together 10 national research laboratories.

India reported more than 400,000 new Covid-19 cases for the first time on Saturday. The rampaging infections have collapsed its health system in places including capital New Delhi, with shortages of medical oxygen and hospital beds.

Opinion

Editorial

Slow start
Updated 15 Jun, 2024

Slow start

Despite high attendance, the NA managed to pass only a single money bill during this period.
Sindh lawlessness
Updated 15 Jun, 2024

Sindh lawlessness

A recently released report describes the law and order situation in Karachi as “worryingly poor”.
Punjab budget
15 Jun, 2024

Punjab budget

PUNJAB’S budget for 2024-25 provides much fodder to those who believe that the increased provincial share from the...
Budget and politics
Updated 14 Jun, 2024

Budget and politics

PML-N, scared of taking bold steps lest it loses whatever little public support it has, has left its traditional support — traders — virtually untouched.
New talks?
14 Jun, 2024

New talks?

WILL this prove another false start, or may we expect a more sincere effort this time? Reference is made to the...
A non-starter
14 Jun, 2024

A non-starter

WHILE the UN Security Council had earlier this week adopted a US-backed resolution calling for a ceasefire in Gaza...