The first days of Pfizer Inc’s Covid-19 vaccine rollout have seen unexpected hitches including some vaccines being stored at excessively cold temperatures and Pfizer reporting potential challenges in its vaccine production, US officials said on a Wednesday press call.

At least two trays of Covid-19 vaccine doses delivered in California needed to be replaced after their storage temperatures dipped below minus 80 Celsius (minus 112 Fahrenheit), US Army General Gustave Perna said on the call. Pfizer’s vaccines, made with partner BioNTech SE, are supposed to be kept at around minus 70C.

Officials are investigating whether storing the vaccines at excessively cold temperatures poses a safety or efficacy risk, he said.

Pfizer also has reported some production issues, US Secretary of Health and Human Services Alex Azar said.

“We will ensure that by whatever mechanism, that we provide them full support to ensure that they can produce for the American people,” Azar said.

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Pfizer did not immediately respond to a request for comment, but its Chief Executive Albert Bourla told CNBC earlier this week the company was asking the US government to use the Defence Production Act to relieve some “critical supply limitations,” particularly in some components. He did not provide further details.

Officials did not outline what the specific manufacturing challenges were.

Ugur Sahin, chief executive of Pfizer’s partner BioNTech, told Reuters last week that Pfizer’s initial 2020 production target of 100 million doses was halved earlier this year in part over issues with raw materials supply. He said that has since been resolved and manufacturing has begun at scale.

Officials said Wednesday they plan to allocate 2 million doses of the Pfizer vaccine next week and 5.9 million doses of Moderna Inc’s, assuming it receives regulatory authorisation. Moderna’s vaccine is likely to be authorised as soon as Friday, they said.

The US government is in talks with Pfizer to secure 100 million additional doses, US Operation Warp Speed chief adviser Dr Moncef Slaoui said on the call. It had previously contracted with Pfizer for the option to buy up to 500 million additional doses at an unspecified price.

Officials said on Wednesday the United States has already contracted for 300 million vaccine doses between the Pfizer/BioNTech shot and one from Moderna in the first half of next year, and 900 million doses in total from drugmakers developing Covid-19 vaccines.

Officials said logistics companies United Parcel Services Inc and FedEx Corp are developing contingency plans for vaccine deliveries this week in response to forecasts of severe snowstorms in some parts of the United States.