The mayor of San Francisco on Friday ordered new lockdowns and business restrictions across the Bay Area in the face of the Covid-19 surge, as political leaders nationwide ramp up pressure on Americans to stay home until vaccines can be distributed, Reuters reports.

The new measures announced by Mayor London Breed, a first-term Democrat, apply across five Bay Area counties and are among the harshest of any major US city, closing all personal services, outdoor dining and most public gatherings.

“What we are seeing in our city, our region, our state and our country is a virus that is taking over,” Breed, 46, said in announcing the new clamp down.

California Governor Gavin Newsom, also a Democrat, said on Thursday he would impose similar stay-at-home orders statewide, to take effect region-by-region as intensive care beds reach capacity.