Hydrocortisone helps sickest Covid-19 patients: UK study

03 Sep 2020

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Some 403 patients at 88 hospitals in the UK study received hydrocortisone via an intravenous drip rather than in pill form. — AFP/File
Some 403 patients at 88 hospitals in the UK study received hydrocortisone via an intravenous drip rather than in pill form. — AFP/File

Commonly available anti-inflammatory drugs have been found to reduce the mortality rate of the sickest Covid-19 patients by 20 per cent, researchers said on Thursday.

Professor Anthony Gordon, of Imperial College London, was part of a British team investigating the effectiveness of hydrocortisone on people on ventilators in intensive care.

The results of the United Kingdom study were compared with those of six others around the world also looking at whether similar corticosteroid drugs could be used in treatment.

“Taking the data from all the seven trials combined, in the patients who weren't treated with steroids, about 40 per cent died from this severe Covid-19,” Gordon told AFP.

“In the groups that were given the various steroids, 32 per cent, roughly, died, so that's a 20 per cent reduction in the risk [...] That means if you treat 100 patients giving them steroids, you would expect to save eight lives, which is really impressive to see a result like that.”

The head of Britain's state-run National Health Service in England, Simon Stevens, called it a “further weapon in the armoury in the worldwide fight against Covid-19”.

“Just as we did with dexamethasone, the NHS will now take immediate action to ensure that patients who could benefit from treatment with hydrocortisone do so,” he added.

Gordon, who combines research with work as a hospital intensive care specialist, said the results were “clear evidence” that steroids help the most severely ill patients.

But he stressed that the steroids, which are often found in over-the-counter medications, should not be used for prevention of Covid-19 or as a home remedy for viral infections.

Some 403 patients at 88 hospitals in the UK study received hydrocortisone via an intravenous drip rather than in pill form, he said.

The similar effectiveness of different corticosteroids could help in the treatment of the disease around the world, alleviating pressure on supply chains, he added.

“Clinicians may be more familiar using one or more of these drugs [...] Having this choice, a greater drug supply, is good news.”

The results of a UK trial of dexamethasone were published in July, showing that mortality rates of patients with Covid-19 were reduced by just under a third.

Among those on ventilators, the death rate for patients on the anti-inflammatory drug was 29.3 percent compared with 41.4 percent for those without.

Gordon said that although the latest results were “consistent” and “encouraging”, further treatments were still needed for the coronavirus.