Genetic mutation study finds new coronavirus spread swiftly in late 2019

Published May 6, 2020
Researchers identify almost 200 recurrent mutations in the novel coronavirus. — AP/File
Researchers identify almost 200 recurrent mutations in the novel coronavirus. — AP/File

A genetic analysis of samples from more than 7,500 people infected with Covid-19 suggests the new coronavirus spread quickly around the world late last year and is adapting to its human hosts, scientists said on Wednesday.

A study by scientists at University College London's (UCL) Genetics Institute found almost 200 recurrent genetic mutations of the new coronavirus — SARS-CoV-2 — which the researchers said showed how it may be evolving as it spreads in people.

Also read: Study finds 33 mutations of coronavirus. Here's what it means for vaccine development

Francois Balloux, a UCL professor who co-led the research, said results showed that a large proportion of the global genetic diversity of SARS-CoV-2 is found in all of the hardest-hit countries. That suggests that the virus was already being transmitted extensively around the globe from early on in the epidemic.

“All viruses naturally mutate. Mutations in themselves are not a bad thing and there is nothing to suggest SARS-CoV-2 is mutating faster or slower than expected,” said Balloux. “So far we cannot say whether SARS-CoV-2 is becoming more or less lethal and contagious.”

More than 3.68 million people have been reported to be infected by the novel coronavirus globally and 256,000 have died, according to a Reuters tally. Infections have been reported in more than 210 countries and territories since cases were first identified in China in December 2019.

The UCL team's findings, published on Wednesday in the journal Infection, Genetics and Evolution, confirm that the virus emerged in late 2019, Balloux said, before quickly spreading across the globe.

The study was not able to confirm the exact starting point or location.

Balloux's team screened the genomes of more than 7,500 viruses from infected patients around the world. Their results add to a growing body of evidence that SARS-CoV-2 viruses share a common ancestor from late 2019, suggesting this was when the virus jumped from a previous animal host into people.

This means it is most unlikely the virus causing Covid-19 was in human circulation for long before it was first detected, Balloux said.

A study by French scientists published earlier this week found a man there was infected with Covid-19 as early as December 27, nearly a month before France confirmed its first cases.

The World Health Organisation said the French case was “not surprising” and urged countries to investigate any other early suspicious cases.

Balloux said the 198 small genetic changes, or mutations, that the study identified appeared to have independently occurred more than once. These may hold clues to how the virus is adapting and help in efforts to develop drugs and vaccines.

“A major challenge to defeating viruses is that a vaccine or drug might no longer be effective if the virus has mutated,” Balloux said. “If we focus our efforts on parts of the virus that are less likely to mutate, we have a better chance of developing drugs that will be effective in the long run.”

Opinion

Editorial

Ties with Tehran
Updated 24 Apr, 2024

Ties with Tehran

Tomorrow, if ties between Washington and Beijing nosedive, and the US asks Pakistan to reconsider CPEC, will we comply?
Working together
24 Apr, 2024

Working together

PAKISTAN’S democracy seems adrift, and no one understands this better than our politicians. The system has gone...
Farmers’ anxiety
24 Apr, 2024

Farmers’ anxiety

WHEAT prices in Punjab have plummeted far below the minimum support price owing to a bumper harvest, reckless...
By-election trends
Updated 23 Apr, 2024

By-election trends

Unless the culture of violence and rigging is rooted out, the credibility of the electoral process in Pakistan will continue to remain under a cloud.
Privatising PIA
23 Apr, 2024

Privatising PIA

FINANCE Minister Muhammad Aurangzeb’s reaffirmation that the process of disinvestment of the loss-making national...
Suffering in captivity
23 Apr, 2024

Suffering in captivity

YET another animal — a lioness — is critically ill at the Karachi Zoo. The feline, emaciated and barely able to...