Palestinians gather around a destroyed car after an explosion in Gaza City. -AP Photo

GAZA CITY: Two people were killed in an Israeli air strike on a car in Gaza City during the Muslim Eid al-Adha holiday on Wednesday, a Palestinian medical source said.

Emergency services spokesman Adham Abu Selmiya confirmed two men had been killed in the strike, naming them as Mohammed Yassin and his brother, Islam, telling AFP they had died “in an Israeli strike on a car in the Samer area of Gaza City.”

The brothers were critically wounded in the strike, which completely obliterated the back of their car, and were rushed to Gaza City's Shifa hospital where they both died shortly afterwards.

A witness told AFP he saw an Israeli warplane fire at a white car in the city centre.

The Israeli army had no immediate comment on the raid, which was the fourth air strike on Gaza within two weeks.

On November 3, Israeli warplanes fired a missile at another car in Gaza City, killing Mohammed al-Nemnem, a senior militant with the Army of Islam, a radical group that espouses an ideology similar to Al-Qaeda.

The army confirmed the strike, describing Nemnem as a “ticking bomb” in what appeared to signal a return to the army's policy of targeted killings.

A month earlier, Israel admitted targeting another militant in an air strike on Gaza City but the man escaped unharmed.

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