Israeli military strikes across Gaza have killed at least 22 people, Palestinian medics said, as the US stepped up efforts to overcome sticking points between Israel and Hamas to reach a ceasefire to end the onslaught.

One of the airstrikes killed at least 10 people in a multi-storey house in the Sheikh Radwan neighborhood of Gaza City, while another killed five in the nearby Zeitoun suburb, medics said.

In Deir Al-Balah city in central Gaza, where hundreds of thousands of Palestinians are sheltering, an Israeli airstrike killed three other people.

In Jabalia, where the army has operated for more than three weeks, an Israeli airstrike killed four people, medics said.

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