The settlers have reached Jabal al-Arma, a hill on the outskirts of the Palestinian town of Beita in the occupied West Bank, Wafa news agency reports.
Within the town of Beita, sirens have gone off warning residents of a potential settler attack, according to Wafa.
Israeli settlers, sometimes given cover by Israeli security forces, have intensified assaults on Palestinian towns during the onslaught on Gaza, waging more than 800 attacks that have caused casualties or property damage, according to the UN Office for the Coordination of Humanitarian Affairs.