Azhar Ali fell 20 runs short of what would have been his third ODI ton. — AP
Mohammad Nawaz followed his skipper two overs later when he walked down the wicket only to be deceived by Moeen Ali's off-spin to be stumped.
Mohammad Rizwan, playing his first ODI in England, was trapped LBW in the 34th over by Rashid, the pick of the bowlers with his three for 47 in 10 overs.
Four overs ago, Pakistan had lost their crucial fourth wicket in Sarfraz Ahmed, who replaced Babar Azam after he Rashid into Liam Plunkett's hand at backward-point, after Azhar registered his ninth ODI fifty.
The wicketkeeper batsman handed Liam Plunkett, at mid-on, a catch off Rashid after scoring just 12 off 23 balls.
Pakistan's top five batsmen, excluding their skipper, added 70 runs — 10 less than Azhar — in 114 balls.
The visitors lost their first wicket early on when Sharjeel Khan, who scored 16 off 12, fell on the last ball of the fourth over off Chris Jordan's full-length delivery.
Trying to muscle Jordan over cover boundary, the left-hander lifted the ball as he played a half-hearted shot. Stokes, who remained brilliant in the field, ran back to capture the ball safely.
The 27-year-old hit three boundaries — two fours and a six.
Ten overs later, his opening partner Sami Aslam made his way back to the pavilion as he was dismissed for 24 off 44 ball by Liam Plunkett.
Toss
Pakistan elected to bat first after winning the toss.
After being clubbed for a record 444 runs in the last ODI, Pakistan made four changes in their line-up.
Mohammad Amir, Shoaib Malik, Wahab Riaz, and Yasir Shah were dropped for Irfan, Rizwan, Gul, and Imad.
England captain made three changes in his playing XI as Jonny Bairstow, David Willy, and Jordan came in for Jos Buttler, Chris Woakes, and Mark Wood.
Pitch and weather report: It was another dry wicket on the offering for the two sides. The pitch was deemed as a pristine batting surface by David Lloyd. The sun basked throughout the day and skies were clear in the evening.
Team line-ups:
England: 1 Jason Roy2 Alex Hales3 Joe Root4 Eoin Morgan (C)5 Ben Stokes6 Jonny Bairstow (W)7 Moeen Ali8 David Willey9 Liam Plunkett10 Adil Rashid11 Chris Jordan
Pakistan: 1 Sami Aslam2 Sharjeel Khan3 Azhar Ali (C)4 Babar Azam5 Sarfraz Ahmed (W)6 Mohammad Rizwan7 Mohammad Nawaz8 Imad Wasim9 Umar Gul10 Hasan Ali11 Mohammad Irfan