WASHINGTON: An experimental drug from a Swiss pharma giant reduced deaths from chronic heart failure by 20 per cent when compared to an existing treatment, according to the results of a vast new study.

The new drug, called LCZ696, has been labelled a potential “blockbuster” with sales in the billions of dollars, say analysts.

Cardiovascular failure, in which the heart does not pump blood effectively, kills at least 26 million people a year worldwide.

Novartis unveiled the highly anticipated results on Saturday at a meeting of the European Society of Cardiology in Barcelona, Spain, and simultaneously in an article in the New England Journal of Medicine.

The study — conducted with more than 8,400 patients in 47 countries over 27 months — compared the safety and effectiveness of the drug on patients with heart failure to the current gold standard, Enalapril.

At the end of the observation period, 21.8 per cent of participants taking LCZ696 died from heart failure, one-fifth lower than the 26.5 per cent who died taking Enalapril.

Novartis plans to request authorisation to bring the medication to market from the US drug regulator by the end of the year, and from the European Union equivalent in early 2015.

It said in a statement that the results were “highly significant and clinically important”.

The drug also reduced hospitalisations by 21 per cent, the study showed.

“I think that when physicians see these data, they will find it compelling, and what we will see is a paradigm shift,” said Milton Packer, a clinical sciences professor at the University of Texas and a co-author of the study.

Despite existing treatments, the mortality rate from heart failure remains high, with around 50 per cent of patients dying within five years of diagnosis, Novartis said.

The condition leads to shortness of breath, fatigue, and fluid retention in the arms and legs.

Published in Dawn, September 1st, 2014