More recently, in a move echoing American lifestyle guru Martha Stewart, she launched The Home Label, an interior decor website selling products endorsed by her.
Adhuna Akhtar, who is married to actor-director Farhan Akhtar, is another high-profile Bollywood wife, working as one of the country's leading hairstylists.
Her success led to her starring in a makeover reality television show earlier this year in which she offered free haircuts and styling advice to young women.
The 44-year-old Akhtar now has 17 high-profile salons scattered across India with plans to open in Dubai.
Increasing job opportunities for women
The first ladies of Bollywood weren't always such a staple of Indian popular culture.
As recently as ten years ago, few film fans paid them much heed, according to Mumbai novelist and commentator Shobhaa De.
“For decades Bollywood's star wives were kept in virtual purdah and allowed out for an airing occasionally... generally at funerals,” De told AFP.
At the time, they were largely perceived as housewives who suffered in silence behind closed doors while rumours flew about their husbands' alleged affairs with glamorous co-stars.
Since then, a younger, assertive and ambitious generation of Bollywood wives has emerged.
Sujata Assomull Sippy, a former editor of Harper's Bazaar India who put Sussanne Roshan on the magazine's cover, said the trend was “part of a wider female empowerment story in India”, as increasing numbers of women join the labour force.
“When Sussanne married Hrithik Roshan she was just a pretty girl, but the minute she opened her store, her profile shot up. Women want to emulate her because she works,” she told AFP.
“You can't become a Bollywood star at 40, but you can turn a passion for interiors or fashion or whatever into a business, into a career, even after you have had kids. And women are drawn to that when they see Sussanne,” she said.
According to a Gallup poll released last month, only 25 per cent of Indian women participate in the labour force compared with 80 per cent of Indian men.
Analysts expect that figure to grow as India's economy expands; creating job opportunities that can be accessed by larger numbers of women.
Those occupying high-profile senior positions in the corporate sector include Kiran Mazumdar-Shaw, founder of biotech giant Biocon, Chanda Kochhar, managing director of ICICI Bank and Shikha Sharma, managing director of Axis Bank.
Being married to one of India's most famous men helps to keep Roshan and her business ventures in the spotlight, as she readily acknowledges.
“It's a huge bonus, no question, but my idea of success really isn't about being married to a movie star,” she said.
“I think it's very important for any woman - especially in India - to aspire to be independent, to be your own person and speak up for yourself. Women today aspire to do much more than just look good.”