August 15, 2008	Friday	Sha'aban 12, 1429

WASHINGTON: Precisely targeted radiation therapy can eradicate tumours that have spread to other parts of the body, offering more months or years of life to patients who have no other options, US have researchers reported.

They said new radiation techniques can attack metastases tumours that have spread one by one.

Experiments in 29 patients showed the radiation stopped all the tumours in six, or 21 per cent, of the patients, for anywhere between 10 months and more than two years.

“This was proof of principle in patients who had failed the standard therapies and had few, if any, remaining options,” said Dr Ralph Weichselbaum of the University of Chicago Medical Center, who led the study.

But the results were inconsistent in another six patients, only the treated tumours grew, while in yet another six, untreated tumours remained and grew, the team at the University of Chicago Medical Center reported in the journal Clinical Cancer Research.

In eight of the patients, new tumours appeared but the treated tumours were stopped.

Higher doses of radiation have been shown to be safe for many places on the body and might work better, Weichselbaum said in an interview.

He said more patients with a variety of cancers, including lung, head and neck, breast, colon and ovarian, are being treated now with higher doses and are surviving longer.

All have stage IV cancer, meaning it has spread to more than one place throughout the body. Almost all patients with stage IV cancer die, even with chemotherapy, except for patients with testicular cancer and some blood cancers.

These patients had been through experimental treatments, so it is not like we got anybody who had standard of care left, Weichselbaum said.

Each volunteer got three doses of precisely targeted radiation to their tumours. New guided radiation techniques can limit the amount of damage to healthy tissue and new imaging techniques, such as CT and PET scans, can help doctors find tumours they previously might have missed.

All the patients had some fatigue but few had serious side effects. One developed severe vomiting and another had internal bleeding that required a blood transfusion.

“Although our radiation wasn’t able to control the disease in everybody, if we had treated where they had recurred with further radiation, surgery or other types of ablation, they could have been rendered disease-free,” Dr Joseph Salama, who worked on the study, said.

“Not all metastatic cancer is the same. In some people, more aggressive therapy can potentially be beneficial,” Salama added.—Reuters