July 30, 2008	Wednesday	Rajab 26, 1429

NEW YORK: Infants born prematurely are at increased risk for a chronic lung disease, called bronchopulmonary dysplasia, associated with prolonged use of oxygen therapy or a respirator.

A new study shows that bronchopulmonary dysplasia as a complication of extreme preterm birth is strongly associated with reduced lung function and structural abnormalities, notably emphysema, in adulthood.

Dr Daniel C. Chambers from Brisbane’s Prince Charles Hospital in Queensland, Australia and colleagues report their findings in the European Respiratory Journal for August.

Bronchopulmonary dysplasia, or BPD, affects up to one-third of infants born prematurely, with impaired lung function persisting into childhood.

Chambers and associates identified 21 people born in Western Australia between 1980 and 1987 prematurely weighing less than 1,500 grams and who required a respirator.

Lung function tests performed when they were about 19 years old showed that 15, or 71 per cent, had persistent respiratory symptoms, including wheeze, cough, and shortness of breath.

CT images of the lungs revealed structural abnormalities in all 19 subjects examined, with 84 per cent having emphysema.

As technological advances increase survival of the most premature newborns, BPD-associated adult lung disease is likely to be seen more frequently, Chambers and his associates warn.

Physicians, they advise, “will need to become increasingly prepared” to ask about the birth history, recognise lung disease potentially associated with prematurity, and offer smoking cessation advice and long-term follow-up to young adults born preterm “as they move past maximum lung growth and into their late 20s and 30s”.—Reuters