The horse, who made a winning return last month after two years out through injury, is owned by Lady Lloyd Webber, wife of the composer Andrew Lloyd Webber.
When some of the higher-weights dropped out at Thursday’s final declarations stage, Killusty made it into the field which is restricted to 40 for safety reasons.
Because of his absence he has got into the race on a low mark and trainer Charlie Egerton has booked top jockey Norman Williamson.
In nine-career starts, Killusty has finished first eight times but he has yet to tackle Aintree’s formidable fences.
Latest betting:
7-1 Ad Hoc
8-1 Shotgun Willy
10-1 Youlneverwalkalone, Chives
11-1 Gingembre
12-1 Monty’s Pass, Iris Bleu, Maximise, Gunner Welburn
14-1 Killusty
20-1 Behrajan
25-1 Carbury Cross
28-1 Bindaree, Goguenard
33-1 Amberleigh House, Ballinclay King, Montifault
40-1 Red Striker, Royal Predica, Supreme Glory
50-1 Blowing Wind, Djeddah, The Bunny Boiler, You’re Agoodun
66-1 and upwards others.