PARIS, May 20: In a world first, neurosurgeons in the US said on Friday electrodes implanted in the lower spine had enabled a paraplegic man to stand up unaided, move his legs voluntarily and, with help, walk on a treadmill.

The therapy marked an exciting advance in the quest to overcome crippling injuries of the spinal cord, they said.

“This is a breakthrough,” said Susan Harkema, a professor at the Spinal Cord Research Centre at the University of Louisville, Kentucky, who led the 11-member team of researchers.

“It opens up a huge opportunity to improve the daily functioning of these individuals... but we have a long road ahead.”

The work, published online by The Lancet, was carried out on a young volunteer, now aged 25, who had been completely paralysed below the chest after a tragic hit-and-run accident in 2006.

Today, after 26 months of retraining of the leg muscles, followed by the pioneering surgery, the patient can reach a standing position and support his own weight for up to four minutes at a time.

Helped by a harness support and some assistance from a therapist, he can make repeated stepping motions on a treadmill. He can also voluntarily move his toes, ankles, knees and hips on command.

The patient, Rob Summers, said he was ecstatic. “This procedure has completely changed my life,” he said.

“For someone who for four years was unable to even move a toe, to have the freedom and ability to stand on my own is the most amazing feeling. To be able to pick up my foot and step down again was unbelievable, but beyond all of that, my sense of wellbeing has changed.

“My physique and muscle tone has improved greatly, so much that most people don't even believe I am paralysed.”

Paralysis comes from damage to the spinal cord down which the brain sends electrical signals along nerve fibres to instruct limb movement.

The research focuses on nerve networks in the lower spine that are relatively autonomous --- they can follow through the commands for weight-bearing and coordinated stepping without input from the brain.

The mechanism works thanks to feedback from nerves in the muscles of the legs and feet that is sent directly to the spinal cord.

It is this sensory input that helps the individual to adjust his balance and speed of movement and level of weight-bearing in response to surfaces and inclines.

“The spinal cord can independently interpret these data and send movement instructions back to the legs --- all without cerebral involvement,” explained Reggie Edgerton, a professor of integrative biology and comparative physiology at the University of California, Los Angeles.

The technique entailed giving Summers 26 months of locomotor training to get his leg muscles used again to the sensation of movement, thus reviving the feedback system.

Surgeons then implanted 16 electrodes in the lumbosacral spinal cord, connecting them to thick nerve bundles that largely control movement of the ankles, hips, knees and toes.

The unit then sent down electrical signals to mimic those sent down the spine by the brain in order to initiate movement.

With Summers, electrostimulation was part of sessions lasting up to 250 minutes.

The success has fired hopes that at least some individuals with spinal paralysis can use a portable stimulation unit to trigger the movements needed to stand up and bear weight. With the help of a walker, it is hoped, such patients would maintain balance and execute some effective stepping.—AFP