The protesters led by JSQM leaders, Lala Suhail Pathan and Riaz Shaikh began their march from Teer Chowk and reached the press club where they staged a protest demonstration.
The leaders alleged that the government had killed many Sindhi leaders in the past, and feared that Dr Safdar Sarki might also have been killed.
They warned the party would launch a strong protest movement if the government did not release Dr Safdar and demanded the government stop bulldozing of Sindhi localities or be prepared to face its outcome.
Later, the protestors offered fateha for the father of Dr Safdar Sarki who had died recently.
CAMPAIGN: The route permit checking campaign will be launched throughout Sukkur district with effect from June 1.
This was announced by the Secretary of District Regional Transport Authority, Sukkur, Mohammad Ibrahim Mahesar, here on Saturday.
Mr Mahesar advised transporters to get their route permits granted/renewed before the deadline passes. In case, any vehicle is found plying without valid route permit, it will be impounded under the Motor Vehicle Rules, he warned.
GUNNED DOWN: Unknown armed men gunned down a man in Mud Khoso village in the jurisdiction of Lakhi police station, Shikarpur district on Friday.
Manzoor Khoso was sitting outside his house, when some armed men sprayed him with bullets and fled.
The brother of the deceased, Suhno Khoso, has registered an FIR against five men and identified them as Mullan, Ghulamullah, Sanaullah, Abdul Wahid and an unidentified man. Police have not yet made any arrest.