New York state’s coronavirus caseload doubled overnight to 22, as the mayor of the nation’s largest city implored the federal government to send more test kits for the new virus.

Mayor Bill de Blasio said the two newly diagnosed patients in New York City, a man in his 40s and a woman in her 80s, both have underlying medical problems that may have intensified their symptoms.

Neither had traveled to virus hotspots or had ties to known cases in the area, adding to indications the virus is spreading locally, AP reported.