Saqlain bowled a marathon spell of 31 overs on the fourth day as Zimbabwe were bowled out for 310 in their second innings — chasing a victory target of 430.
The tireless Saqlain applied relentless pressure on a pitch which did not offer him significant assistance, finishing with figures of three for 98. Speedster Shoaib Akhtar was the other star with figures of four for 75.
Zimbabwe began the day on 19 for one having dismissed Pakistan for 369 in their second innings.
They lost their second wicket in the ninth over of the morning when Alistair Campbell failed to get in line with a delivery from fast bowler Mohammad Sami and was caught behind by wicket-keeper Kamran Akmal for 30.
Grant Flower joined opener Dion Ebrahim at the crease for a stabilising partnership of 111 for the third wicket in which Ebrahim played the anchor role and Flower unfurled several dazzling cover drives.
Pakistan wasted a chance to dismiss Ebrahim for 24 when, with the total 60 for two, Taufiq Umar spilled a chance at third slip off the bowling of Sami.
Four overs before lunch, Saqlain was convinced he had Ebrahim caught behind down the leg side for 60, only for the delivery to be ruled a no ball.
Zimbabwe went to lunch on 154 for two, but Pakistan broke through four overs later when Ebrahim left a delivery from Shoaib Akhtar that reverse swung and uprooted middle stump. Ebrahim scored his 69 off 116 balls and hit nine fours.
Grant Flower then went fishing down the leg side to a delivery from Saqlain and was caught behind for 69 having faced 113 balls.
Saqlain struck again in the next over when Guy Whittall edged a high bouncing delivery to Younis Khan at slip to be dismissed for two.
Andy Flower and Tatenda Taibu bolstered Zimbabwe with a brisk sixth-wicket stand of 53 before Taibu was trapped lbw by fast bowler Waqar Younis for 28 three overs after tea.
Umpire Srinivas Venkataraghavan’s decision seemed harsh as the ball appeared to be missing leg stump.
That proved Zimbabwe’s last meaningful stand, and the match was all over bar the shouting when Flower skied a short ball from Shoaib, with the bowler taking the catch.
Shoaib took his fourth wicket of the innings when he clean bowled Henry Olonga to end the match.
PAKISTAN (1st Innings) 285 (Taufiq Umar 75, Yousuf Youhana 63, Hasan Raza 46, Younis Khan 40; A.M. Blignaut 5-79).
ZIMBABWE (1st Innings) 225 (T. Taibu 51 not out, A.M. Blignaut 50; Mohammad Sami 4-53).
PAKISTAN (2nd Innings) 369 (Inzamam-ul-Haq 112, Taufiq Umar 111; H.K. Olonga 5-93).
ZIMBABWE (2nd Innings, overnight 19-1):
D.D. Ebrahim b Shoaib 69
H. Masakadza c Saleem b Shoaib 0
A.D.R. Campbell c Kamran b Sami 30
G.W. Flower c Kamran b Saqlain 69
A. Flower c and b Shoaib 67
G.J. Whittall c Younis Khan b Saqlain 2
T. Taibu lbw b Waqar 28
A.M. Blignaut c Younis Khan b Saqlain 12
N.B. Mahwire lbw b Waqar 3
R.W. Price not out 5
H.K. Olonga b Shoaib 5
EXTRAS (B-8, LB-6, W-1, NB-5) 20
TOTAL (all out, 310
FALL OF WKTS: 1-4, 2-51, 3-162, 4-201, 5-203, 6-256, 7-280, 8-291, 9-301.
BOWLING: Waqar Younis 16-1-73-2; Shoaib Akhtar 18.3-4-75-4 (1w); Mohammad Sami 15-3-50-1 (2nb); Saqlain Mushtaq 31-4-98-3 (3nb); Taufiq Umar 1-1-0-0.
RESULT: Pakistan won by 119 runs.
UMPIRES: D.L. Orchard (South Africa) and S. Venkataraghavan (India).
TV UMPIRE: I.D. Robinson (Zimbabwe).
MATCH REFEREE: C.H. Lloyd (West Indies).
MAN-OF-THE-MATCH: Taufiq Umar.
SECOND TEST: Bulawayo, Nov 16-20.—Reuters