Three Zebra fish, which were injected with a green fluorescent protein gene from a jellyfish and a red gene from a sea anemone into its embryo, are seen glowing under ultra-violet light in Singapore, 24 May 2001. — AFP Photo

PARIS, April 17, 2013 - One of the world's most popular aquarium fishes on Wednesday joined the rat, the mouse, fruitfly and nematode worm in the roll call of creatures whose DNA has been sequenced to help fight disease among humans.

A consortium of researchers unveiled the genome of the zebrafish in the British journal Nature, declaring it made a vital model for pinpointing faulty genes.

The tiny striped fish - Danio rerio in Latin - has 26,000 genes, 70 percent of which are shared with humans.

Eighty-four percent of genes known to be associated with human disease have a zebrafish counterpart.

The fish has a brief life cycle and in the embryonic stage is transparent, which makes it highly useful in the lab.

The zebrafish has already unlocked insights into cancer and heart disease and advanced knowledge of muscle and organ development, including genes implicated in muscular dystrophy.

“We can readily create variations in their genome that are relevant to human health and disease. This has allowed a greater understanding of gene function and the finding of new targets for drug treatments,” said Leonard Zon of the Children's Hospital of Boston, Massachusetts.

“Several small molecules discovered using the zebrafish system have recently entered clinical trials,” he said in a press release.

“The availability of the genome sequence, coupled with the rapid expansion of disease models and chemical screening ability, ensures that the zebrafish system has a major place in biomedicine.”

Opinion

Editorial

Ties with Tehran
Updated 24 Apr, 2024

Ties with Tehran

Tomorrow, if ties between Washington and Beijing nosedive, and the US asks Pakistan to reconsider CPEC, will we comply?
Working together
24 Apr, 2024

Working together

PAKISTAN’S democracy seems adrift, and no one understands this better than our politicians. The system has gone...
Farmers’ anxiety
24 Apr, 2024

Farmers’ anxiety

WHEAT prices in Punjab have plummeted far below the minimum support price owing to a bumper harvest, reckless...
By-election trends
Updated 23 Apr, 2024

By-election trends

Unless the culture of violence and rigging is rooted out, the credibility of the electoral process in Pakistan will continue to remain under a cloud.
Privatising PIA
23 Apr, 2024

Privatising PIA

FINANCE Minister Muhammad Aurangzeb’s reaffirmation that the process of disinvestment of the loss-making national...
Suffering in captivity
23 Apr, 2024

Suffering in captivity

YET another animal — a lioness — is critically ill at the Karachi Zoo. The feline, emaciated and barely able to...